Dépôt numérique
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Liposomal structure: A comparative study on light scattering and chromatography techniques

Maherani, Behnoush; Wattraint, Olivier (2017). Liposomal structure: A comparative study on light scattering and chromatography techniques Journal of Dispersion Science and Technology , vol. 38 . p. 1633-1639. DOI: 10.1080/01932691.2016.1269651.

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Résumé

Liposomes play an important role in medical and pharmaceutical science as, nanoscale drug carriers. One of the most important features is their size and size distribution, influencing both their bio-distribution and their targeting efficiency to tumors and also therapeutic activity of liposomal antitumor drugs. In this study, the effect of preparation method and molecular interaction on size and shape of liposome was studied. The size and shape characterization of liposomes was performed by asymmetrical flow field-flow fractionation coupled online with multi-angle light scattering (AF4-MALS). The size distributions obtained by AF4-MALS were compared to mean particle sizes and size distribution measured with other standard method such as Photon Correlation Spectroscopy (PCS). Furthermore, the effect of molecular interaction (hydrophilic and hydrophobic model drugs) on liposomal structure was assessed.

Type de document: Article
Mots-clés libres: AF4; light scattering technique; molecular interaction; nanoliposome; ρ values; Fractionation; Liposomes; Liquid chromatography; Molecular interactions; Molecular structure; Photon correlation spectroscopy; Size distribution; Asymmetrical Flow Field Flow Fractionation; Hydrophilic and hydrophobic; Light scattering techniques; Multi-angle light scatterings; Pharmaceutical science; Size and size distributions; Therapeutic activity; Light scattering
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 févr. 2019 15:39
Dernière modification: 22 févr. 2019 15:39
URI: http://espace.inrs.ca/id/eprint/5403

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