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Statins can exert dual, concentration dependent effects on HCV entry in vitro

Blanchet, Matthieu; Le, Quoc-Tuan; Seidah, Nabil G.; Labonte, Patrick (2016). Statins can exert dual, concentration dependent effects on HCV entry in vitro Antiviral Research , vol. 128 . p. 43-48. DOI: 10.1016/j.antiviral.2016.02.006.

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Résumé

Statins are used daily by a large and increasing number of individuals worldwide. They were initially designed as 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) inhibitors to treat patients with hypercholesterolemia. Recent studies on HCV chronically infected individuals have suggested that their use in vivo in combination with PEG-IFN and ribavirin favor the sustained viral response (SVR). Herein, we describe the effects of a set of statins on HCV entry and on HCV key entry factors in vitro. Our results suggest that all tested statins exert a proviral effect through the upregulation of LDLR. Interestingly, at higher concentration, we also provide evidence of a yet unknown competing antiviral effect of statins (except for pravastatin) through the downregulation of CLDN-1. Importantly, this work enlightens the blunt proviral effect of pravastatin at the entry step of HCV in vitro

Type de document:
Mots-clés libres: HCV; Statins; CLDN-1; LDLR; NPC1L1; CD81; PCSK9; Lipids; Cholesterol
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 09 mai 2017 20:48
Dernière modification: 09 mai 2017 21:04
URI: http://espace.inrs.ca/id/eprint/4560

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