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Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia

Silva-Barrios, Sasha; Smans, Mélina; Duerr, Claudia; Qureshi, Salman; Fritz, Jorg; Descoteaux, Albert; Stäger, Simona (2016). Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia Cell Reports , vol. 15 , nº 11. p. 2427-2437. DOI: 10.1016/j.celrep.2016.05.028.

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Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response. B cell activation by Leishmania donovani results in disease exacerbation. How Leishmania activates B cells is still unknown. We show that L. donovani amastigotes activate B cells by triggering endosomal TLRs; this activation leads to the induction of various cytokines. Cytokine expression is completely abrogated in B cells from Ifnar(-/-) mice upon exposure to L. donovani, suggesting an involvement of IFN-I in a positive feedback loop. IFN-I also appears to enhance the expression of endosomal TLRs following exposure to L. donovani. Cell-specific ablation of endosomal TLR signaling in B cells revealed that innate B cell activation by L. donovani is responsible for disease exacerbation through IL-10 and IFN-I production and for the promotion of hypergammaglobulinemia.

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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 24 août 2016 18:17
Dernière modification: 11 janv. 2017 19:45
URI: http://espace.inrs.ca/id/eprint/4536

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