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Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells

Lapierre, Pascal; Janelle, Valérie; Langlois, Marie-Pierre; Tarrab, Esther; Charpentier, Tania; Lamarre, Alain (2015). Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells CMGH Cellular and Molecular Gastroenterology and Hepatology , vol. 1 , nº 3. p. 325-341. DOI: 10.1016/j.jcmgh.2015.02.002.

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Résumé

Expression by the liver of a viral protein induced an immunologic tolerance mediated by interleukin-10-secreting regulatory T cells that impaired the antiviral T-cell response, leading to a chronic infection. This mechanism could be involved in the establishment of persistent infection by hepatotropic viruses.

Type de document:
Mots-clés libres: Chronic Infection; Hepatitis; Tolerance
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 mars 2016 19:24
Dernière modification: 10 mars 2016 19:24
URI: http://espace.inrs.ca/id/eprint/3211

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