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Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects

Dagenais-Lussier, Xavier; Mouna, Aounallah; Routy, Jean-Pierre; Tremblay, Cécile; Sekaly, Rafick-Pierre; El-Far, Mohamed; Grevenynghe, Julien van (2015). Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects Cytokine and Growth Factor Reviews , vol. 26 , nº 6. p. 603-13. DOI: 10.1016/j.cytogfr.2015.09.001.

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Résumé

HIV-1 infection results in long-lasting activation of the immune system including elevated production of pro-inflammatory cytokine/chemokines, and bacterial product release from gut into blood and tissue compartments, which are not fully restored by antiretroviral therapies. HIV-1 has also developed numerous strategies via viral regulatory proteins to hijack cell molecular mechanisms to enhance its own replication and dissemination. Here, we reviewed the relationship between viral proteins, immune activation/inflammation, and deregulated metabolism occurring in HIV-1-infected patients that ultimately dampens the protective innate and adaptive arms of immunity. Defining precisely the molecular mechanisms related to deregulated immuno-metabolism during HIV-1 infection could ultimately help in the development of novel clinical approaches to restore proper immune functions in these patients.

Type de document:
Mots-clés libres: HIV-1; Immuno-metabolism; Inflammation; Innate/adaptive immunity
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 19 juin 2017 20:35
Dernière modification: 19 juin 2017 20:35
URI: http://espace.inrs.ca/id/eprint/3173

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