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Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils

Simard, Jean-Christophe; Noël, Claudie; Tessier, Philippe A; Girard, Denis (2014). Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils FEBS Letters , vol. 588 , nº 13. p. 2141-2146. DOI: 10.1016/j.febslet.2014.04.027.

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Résumé

Inflammation is highly regulated by various agents. Unexpectedly, we report here that the damage-associated molecular pattern S100A9 protein, a potent neutrophil activator and inducer of cytokine production in monocytes, is not a direct activator of cytokine production in human neutrophils. However, S100A9 primed IL-8 production in fMLP- and GM-CSF-stimulated neutrophiles via NF-κB and CREB-1, and NF-κB, STAT3 and STAT5, respectively. Pharmacological inhibition confirmed the importance of these transcription factors by significantly decreasing IL-8 production. This is the first time that a different set of transcription factors are shown to be involved in S100A9-primed neutrophils in response to proinflammatory agonist. © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Mots-clés libres: CREB-1 Neutrophil NF-κB S100A9 STAT-3 STAT-5
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 03 avr. 2017 20:55
Dernière modification: 03 avr. 2017 20:55
URI: http://espace.inrs.ca/id/eprint/3113

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