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Expression and functions of galectin-7 in ovarian cancer

Labrie, Marilyne; Vladoiu, Maria Claudia; Grosset, Andrée-Anne; Gaboury, Louis; St-Pierre, Yves (2014). Expression and functions of galectin-7 in ovarian cancer Oncotarget , vol. 5 , nº 17. p. 7705-7721. DOI: 10.18632/oncotarget.2299.

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Résumé

There is a critical need to develop effective new strategies for diagnosis and treatment of ovarian cancer. In the present work, we investigated the expression of galectin-7 (gal-7) in epithelial ovarian cancer (EOC) cells and studied its functional relevance. Immunohistochemical analysis of gal-7 expression in tissue microarrays showed that while gal-7 was not detected in normal ovarian tissues, positive cytoplasmic staining of gal-7 was detected in epithelial cells in all EOC histological subtypes but was more frequent in high grade tumors and metastatic samples. Gal-7 expression correlated with a significant difference in the overall survival of patients with ovarian serous cystadenocarcinoma. Furthermore, using human EOC cell lines, we found that gal-7 expression was induced by mutant p53. Mechanistically, Matrigel invasion assays and live cell imaging showed that gal-7 increased the invasive behavior of ovarian cancer cells by inducing MMP-9 and increasing cell motility. EOC cells can also secrete gal-7. Recombinant human gal-7 kills Jurkat T cells and human peripheral T cells, suggesting that gal-7 also has immunosuppressive properties. Taken together, our study validates the clinical significance of gal-7 overexpression in ovarian cancer and provides a rationale for targeting gal-7 to improve the outcome of patients with this disease.

Type de document:
Mots-clés libres: Galectin-7 Immunosupression MMP-9 Ovarian cancer P53
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 23 mars 2016 19:22
Dernière modification: 23 mars 2016 19:22
URI: http://espace.inrs.ca/id/eprint/3069

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