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Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles

Acuna, Rodrigo; Cifuentes-Munoz, Nicolas; Marquez, Chantal L.; Bulling, Manuela; Klingstrom, Jonas; Mancini, Roberto; Lozach, Pierre-Yves; Tischler, Nicole D. (2014). Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles Journal of Virology , vol. 88 , nº 4. p. 2344-2348. DOI: 10.1128/JVI.03118-13.

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Résumé

How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera.

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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 mars 2016 21:31
Dernière modification: 08 mars 2016 21:31
URI: http://espace.inrs.ca/id/eprint/2999

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