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Leishmania dices away cholesterol for survival

Descoteaux, Albert; Moradin, Neda; Arango Duque, Guillermo (2013). Leishmania dices away cholesterol for survival Cell Host and Microbe , vol. 13 , nº 3. p. 245-7. DOI: 10.1016/j.chom.2013.02.018.

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Résumé

Host lipid alterations are centrally involved in Leishmania donovani infection, and infected patients exhibit hypocholesterolemia. In this issue of Cell Host amp Microbe, Ghosh et al. (2013) show that the metalloprotease GP63 released by L. donovani in the liver cleaves DICER1, inhibiting miR-122 maturation, which regulates cholesterol metabolism. These events decrease serum cholesterol and promote parasite growth.

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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 mai 2017 19:42
Dernière modification: 10 mai 2017 19:53
URI: http://espace.inrs.ca/id/eprint/2884

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