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PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis

Lépine, François; Dekimpe, Valérie; Lesic, Biliana; Milot, Sylvain; Lesimple, Alain; Mamer, Orval A; Rahme, Laurence G.; Déziel, Éric (2007). PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis Biological Chemistry , vol. 388 , nº 8. p. 839-845. DOI: 10.1515/bc.2007.100.

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Résumé

A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factor

Type de document:
Mots-clés libres: 2,4-dihydroxyquinoline, 4-hydroxy-2-alkylquinolines, mass spectrometry, natural product, Pseudomonas aeruginosa, PqsA
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 01 mai 2014 16:10
Dernière modification: 01 mai 2014 16:10
URI: http://espace.inrs.ca/id/eprint/2229

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